Synthesis of N,N-dialkyl-N′-arylhydrazines via palladium-catalyzed N-arylation by using N,N-dialkylhydrazines/2LiCl adducts

被引:32
作者
Cacchi, S
Fabrizi, G
Goggiamani, A
Licandro, E
Maiorana, S
Perdicchia, D
机构
[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy
[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
关键词
D O I
10.1021/ol050130i
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] The reaction of N,N-dialkylhydrazine/2LiCl adducts with aryl bromides in the presence of Pd-2(dba)(3) as the palladium source, Xantphos or X-phos as the ligands, toluene as the solvent, and NaOBu-t as the base provides an efficient route to N,N-dialkyl-N,-arylhydrazines. Best results were obtained by using N,N-dialkylhydrazine/2LiCl adducts prepared in situ, omitting their isolation.
引用
收藏
页码:1497 / 1500
页数:4
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