Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity

被引：67

作者：

Malavazos, Alexis E.

Ermetici, Federica

Coman, Calin

Corsi, Massimiliano M.

Morricone, Lelio

Ambrosi, Bruno

机构：

[1] Univ Milan, Endocrinol Unit, Dept Med & Surg Sci, IRCCS Policlin San Donato, I-20097 San Donato Milanese, MI, Italy

[2] IRCCS Policlin San Donato, Echocardiog Unit, I-20097 San Donato Milanese, MI, Italy

[3] Univ Milan, Clin Pathol Lab, Inst Gen Pathol, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 121卷 / 01期

关键词：

epicardial adipose tissue; visceral obesity; adipocytokines; echocardiography;

D O I：

10.1016/j.ijcard.2006.08.061

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipocytokine levels and visceral adipose tissue ( VAT) seem to be associated with some cardiac abnormalities and a role of visceral fat in predisposing to cardiac dysfunction, possibly through a low-grade state of inflammation, has been demonstrated. In this study we firstly show that elevated levels of both monocyte chemoattractant protein 1 ( MCP-1) and soluble IL-6 receptor/interleukin-6 ( sIL-6R/IL-6) complex are closely correlated with epicardial fat thickness. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：132 / 134

页数：3

共 15 条

[1] Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease [J].

Baker, Adam R. ;

da Silva, Nancy F. ;

Quinn, David W. ;

Harte, Alison L. ;

Pagano, Domenico ;

Bonser, Robert S. ;

Kumar, Sudhesh ;

McTernan, Philip G. .

CARDIOVASCULAR DIABETOLOGY, 2006, 5 (1)

[2] Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): Implication of macrophages resident in the AT [J].

Bruun, JM ;

Lihn, AS ;

Pedersen, SB ;

Richelsen, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (04) :2282-2289

[3] Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid [J].

Fried, SK ;

Bunkin, DA ;

Greenberg, AS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (03) :847-850

[4] CONTINUOUS ACTIVATION OF GP130, A SIGNAL-TRANSDUCING RECEPTOR COMPONENT FOR INTERLEUKIN 6-RELATED CYTOKINES, CAUSES MYOCARDIAL HYPERTROPHY IN MICE [J].

HIROTA, H ;

YOSHIDA, K ;

KISHIMOTO, T ;

TAGA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4862-4866

[5] Relation between epicardial adipose tissue and left ventricular mass [J].

Iacobellis, G ;

Ribaudo, MC ;

Zappaterreno, A ;

Iannucci, CV ;

Leonetti, F .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (08) :1084-1087

[6] Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction [J].

Iacobellis, G ;

Assael, F ;

Ribaudo, MC ;

Zappaterreno, A ;

Alessi, G ;

Di Mario, U ;

Leonetti, F .

OBESITY RESEARCH, 2003, 11 (02) :304-310

[7]

IACOBELLIS G, IN PRESS INT J CARDI

[8] The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex [J].

Jones, SA ;

Rose-John, S .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2002, 1592 (03) :251-263

[9] Obesity as a medical problem [J].

Kopelman, PG .

NATURE, 2000, 404 (6778) :635-643

[10] Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity [J].

Malavazos, AE ;

Cereda, E ;

Morricone, L ;

Coman, C ;

Corsi, MM ;

Ambrosi, B .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 153 (06) :871-877

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