Cilia are at the heart of vertebrate left-right asymmetry

被引：100

作者：

McGrath, J

Brueckner, M ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Dept Cardiol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(03)00091-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Handed asymmetry of the shape and position of the internal organs is found in all vertebrates, and is essential for normal cardiac development. Recent genetic and embryological experiments in mouse embryos have demonstrated that left-right asymmetry is established by directional flow of extraembryonic fluid surrounding the node, which is driven by motile monocilia.

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页码：385 / 392

页数：8

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