Tackling influenza with broadly neutralizing antibodies

被引：111

作者：

Corti, Davide ^{[1
]}

Cameroni, Elisabetta ^{[1
]}

Guarino, Barbara ^{[1
]}

Kallewaard, Nicole L. ^{[2
]}

Zhu, Qing ^{[2
]}

Lanzavecchia, Antonio ^{[3
]}

机构：

[1] Humabs BioMed SA, CH-6500 Bellinzona, Switzerland

[2] MedImmune, Dept Infect Dis, Gaithersburg, MD 20878 USA

[3] Univ Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland

来源：

CURRENT OPINION IN VIROLOGY | 2017年 / 24卷

关键词：

HUMAN MONOCLONAL-ANTIBODY; VIRUS-INFECTED CELLS; A VIRUS; CONVALESCENT PLASMA; IN-VIVO; EXTRACELLULAR DOMAIN; CONSERVED EPITOPE; FC-RECEPTOR; M2; PROTEIN; B VIRUS;

D O I：

10.1016/j.coviro.2017.03.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses.

引用

页码：60 / 69

页数：10

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