Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: A drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease

被引：96

作者：

Jiang, HL

Luo, XM

Bai, DL

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 21期

关键词：

huperzine A; Alzheimer's disease; acetylcholinesterase; X-ray crystallography; molecular modeling;

D O I：

10.2174/0929867033456747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HupA is a potent, reversible AChEI, which crosses the blood-brain barrier smoothly, and shows high specificity for AChE with a prolonged biological half-life. It has been approved as the drug for the treatment of AD in China, and marketed in USA as a dietary supplement. HupA has been the subject of investigations by an ever-increasing number of researchers since 1980's. In the last four years, HupA has been further studied in many aspects such as the chemical synthesis, structural modification, structure-activity relationship, various biological effects, and mechanisms of action. A number of papers dealing with the computational modeling and X-ray crystallographic studies of HupA-AChE complex have also been published. This review represents a comprehensive documentation of the progress in the studies on HupA during the period of 1999-2002.

引用

页码：2231 / 2252

页数：22

共 110 条

[1] Insecticidal activity of huperzine A from the New Zealand clubmoss, Lycopodium varium [J].

Ainge, GD ;

Lorimer, SD ;

Gerard, PJ ;

Ruf, LD .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (03) :491-494

[2]

Alvarez A, 1998, J NEUROSCI, V18, P3213

[3]

ASHANI Y, 1994, MOL PHARMACOL, V45, P555

[4]

ASHANI Y, 1996, MED DEF BIOSCI REV P, V1, P105

[5] Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease [J].

Badia, A ;

Banos, JE ;

Camps, P ;

Contreras, J ;

Gorbig, DM ;

Munoz-Torrero, D ;

Simon, M ;

Vivas, NM .

BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (04) :427-440

[6] Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease [J].

Bai, DL ;

Tang, XC ;

He, XC .

CURRENT MEDICINAL CHEMISTRY, 2000, 7 (03) :355-374

[7] Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase [J].

Barril, X ;

Orozco, M ;

Luque, FJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) :5110-5119

[8] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[9]

Camps P., 2001, Mini-Reviews in Medicinal Chemistry, V1, P163, DOI 10.2174/1389557013406972

[10] On the regioselectivity of the Friedlander reaction leading to huprines:: stereospecific acid-promoted isomerization of syn-huprines to their anti-regioisomers [J].

Camps, P ;

Gómez, E ;

Muñoz-Torrero, D ;

Arnó, M .

TETRAHEDRON-ASYMMETRY, 2001, 12 (20) :2909-2914

← 1 2 3 4 5 6 7 8 9 10 →