Cytokines and myocardial dysfunction: State of the art

被引：80

作者：

El-Menyar, Ayman A. ^{[1
,2
]}

机构：

[1] Weill Cornell Univ, Fac Med, Doha, Qatar

[2] Hamad Gen Hosp, Dept Cardiol & Cardiovasc Surg, Doha, Qatar

来源：

JOURNAL OF CARDIAC FAILURE | 2008年 / 14卷 / 01期

关键词：

cytokine; heart failure; interleukin; myocardial dysfunction proinflammatory; tumor necrosis factor;

D O I：

10.1016/j.cardfail.2007.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Myocardial dysfunction has been associated with inflammation and cytokine modulation. Objectives: The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction. Methods: Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research. Results: For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time. Conclusion: Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.

引用

页码：61 / 74

页数：14

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