HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

被引：64

作者：

Kim, HJ

Woo, ER

Shin, CG

Hwang, DJ

Park, H

Lee, YS

机构：

[1] Korea Inst Sci & Technol, Nat Prod Chem Lab, Seoul 130650, South Korea

[2] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

[3] Chung Ang Univ, Dept Biotechnol, An Sung 456756, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 04期

关键词：

AIDS; antivirals; HIV-1 integrase inhibitors; Clerodendron trichotomum;

D O I：

10.1007/BF02975093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 muM, respectively.

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页码：286 / 291

页数：6

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