Phage-display technology - finding a needle in a vast molecular haystack

被引：181

作者：

Rodi, DJ ^{[1
]}

Makowski, L ^{[1
]}

机构：

[1] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(99)80016-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Screening of phage-displayed libraries of proteins and peptides has, for nearly a decade, proven to be a highly effective method for finding much needed 'needles' in a vast molecular 'haystack'. Over the past year, it has been used to solve an increasing diversity of problems, including identification of binding motifs for much smaller targets and the use of novel screening methods to identify chemical activities.

引用

页码：87 / 93

页数：7

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