Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes

被引：451

作者：

Wu, W

Wieckowski, S

Pastorin, G

Benincasa, M

Klumpp, C

Briand, JP

Gennaro, R

Prato, M

Bianco, A ^{[1
]}

机构：

[1] CNRS, UPR 9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

[2] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[3] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 39期

关键词：

antibiotics; drug delivery; nanotubes; nanovectors; toxicity;

D O I：

10.1002/anie.200501613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB. (Figure Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：6358 / 6362

页数：5

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