Design and evaluation of anacardic acid derivatives as anticavity agents

被引：20

作者：

Green, Ivan R. ^{[1
]}

Tocoli, Felismino E. ^{[1
]}

Lee, Sang Hwa ^{[2
]}

Nihei, Ken-ichi ^{[2
]}

Kubo, Isao ^{[2
]}

机构：

[1] Univ Western Cape, Dept Chem, ZA-7530 Bellville, South Africa

[2] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 06期

关键词：

anacardic acid; Streptococcus mutans; antibacterial activity; 6-(4; 8 '-dimethylnonyl)salicylic acid;

D O I：

10.1016/j.ejmech.2007.08.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and tested for their antibacterial activity against Streptococcus mutans ATCC 25175. Among them, 6-(4',8'-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 mu g/ml. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1315 / 1320

页数：6

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