Regulation of the human tRNase ZS gene expression

被引：20

作者：

Takahashi, Masayuki ^{[1
]}

Takaku, Hiroaki ^{[1
]}

Nashimoto, Masayuki ^{[1
]}

机构：

[1] Niigata Univ Pharm & Appl Life Sci, Dept Appl Life Sci, Niigata 9568603, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 17期

关键词：

promoter; subcellular localization; transcription; tRNase Z(S); tRNA 3 ' processing;

D O I：

10.1016/j.febslet.2008.06.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are two types of tRNA 30 processing endoribonucleases ( tRNase Z): a short form ( tRNase Z S) and a long form ( tRNase Z L). Although the human genome contains both genes, little is known about the physiological role of tRNase Z S. We found that the human tRNase Z S gene expression appears to be post- transcriptionally regulated. Additionally, analyses for cis- regulatory elements for the tRNase Z S gene transcription suggested that transcription factors that bind to. ve di. erent sites on the promoter work together to potentiate the transcription initiation. Furthermore, we found that tRNase Z S is predominantly present in the cytosol and hardly in the nucleus. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2532 / 2536

页数：5

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