Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

被引：657

作者：

Russell, Shannon L. ^{[2
,3
]}

Gold, Matthew J. ^{[1
]}

Hartmann, Martin ^{[2
,4
]}

Willing, Benjamin P. ^{[3
]}

Thorson, Lisa ^{[3
]}

Wlodarska, Marta ^{[2
,3
]}

Gill, Navkiran ^{[3
]}

Blanchet, Marie-Renee ^{[5
]}

Mohn, William W. ^{[2
,4
]}

McNagny, Kelly M. ^{[1
]}

Finlay, Brett B. ^{[2
,3
]}

机构：

[1] Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

[3] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[4] Univ British Columbia, Inst Life Sci, Vancouver, BC V6T 1Z4, Canada

[5] Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Quebec City, PQ G1V 4G5, Canada

来源：

EMBO REPORTS | 2012年 / 13卷 / 05期

基金：

加拿大健康研究院;

关键词：

antibiotics; asthma; gut; microbiota; TOLL-LIKE RECEPTOR-4; INTESTINAL MICROBIOTA; FUNGAL MICROBIOTA; CHILDHOOD ASTHMA; INCREASED RISK; RESPONSES; CELLS; EXPOSURE; BACTERIA; BALANCE;

D O I：

10.1038/embor.2012.32

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allergic asthma rates have increased steadily in developed countries, arguing for an environmental aetiology. To assess the influence of gut microbiota on experimental murine allergic asthma, we treated neonatal mice with clinical doses of two widely used antibiotics-streptomycin and vancomycin-and evaluated resulting shifts in resident flora and subsequent susceptibility to allergic asthma. Streptomycin treatment had little effect on the microbiota and on disease, whereas vancomycin reduced microbial diversity, shifted the composition of the bacterial population and enhanced disease severity. Neither antibiotic had a significant effect when administered to adult mice. Consistent with the 'hygiene hypothesis', our data support a neonatal, microbiota-driven, specific increase in susceptibility to experimental murine allergic asthma.

引用

页码：440 / 447

页数：8

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