New aminocyclitols as modulators of glucosylceramide metabolism

被引：31

作者：

Egido-Gabás, M

Serrano, P

Casas, J

Llebaria, A

Delgado, A

机构：

[1] CSIC, IIQAB, Dept Quim Organ Biol, Res Unit Bioact Mol RUBAM, ES-08034 Barcelona, Spain

[2] Univ Barcelona, Fac Farm, Unidad Quim Farmaceut, E-08028 Barcelona, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 07期

关键词：

D O I：

10.1039/b411473f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided.

引用

页码：1195 / 1201

页数：7

共 33 条

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*ACC INC, 2002, DSVIEWER PRO V 5 0

[2] Synthesis and glycosidase inhibition of new enantiopure 2,3-diamino conduritols [J].