Growing pains: The cytoskeleton as a critical regulator of pain plasticity

被引:26
作者
Bhave, G [1 ]
Gereau, RW [1 ]
机构
[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
关键词
D O I
10.1016/S0896-6273(03)00500-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic interactions with the cytoskeleton.
引用
收藏
页码:577 / 579
页数:3
相关论文
共 16 条
[1]   DOES COLCHICINE WORK - THE RESULTS OF THE 1ST CONTROLLED-STUDY IN ACUTE GOUT [J].
AHERN, MJ ;
REID, C ;
GORDON, TP ;
MCCREDIE, M ;
BROOKS, PM ;
JONES, M .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1987, 17 (03) :301-304
[2]   Nociceptor sensitization by extracellular signal-regulated kinases [J].
Aley, KO ;
Martin, A ;
McMahon, T ;
Mok, J ;
Levine, JD ;
Messing, RO .
JOURNAL OF NEUROSCIENCE, 2001, 21 (17) :6933-6939
[3]   AKAPs: from structure to function [J].
Colledge, M ;
Scott, JD .
TRENDS IN CELL BIOLOGY, 1999, 9 (06) :216-221
[4]   A Randomized controlled trial to evaluate the slow-acting symptom-modifying effects of colchicine in osteoarthritis of the knee: A preliminary report [J].
Das, SK ;
Ramakrishnan, S ;
Mishra, K ;
Srivastava, R ;
Agarwal, GG ;
Singh, R ;
Sircar, AR .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2002, 47 (03) :280-284
[5]   Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade - Role of focal adhesions and receptor tyrosine kinases [J].
Della Rocca, GJ ;
Maudsley, S ;
Daaka, Y ;
Lefkowitz, RJ ;
Luttrell, LM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) :13978-13984
[6]   Role of the sensory neuron cytoskeleton in second messenger signaling for inflammatory pain [J].
Dina, OA ;
McCarter, GC ;
de Coupade, C ;
Levine, JD .
NEURON, 2003, 39 (04) :613-624
[7]   Drug therapy - The management of gout [J].
Emmerson, BT .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (07) :445-451
[8]   Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction [J].
Faux, MC ;
Rollins, EN ;
Edwards, AS ;
Langeberg, LK ;
Newton, AC ;
Scott, JD .
BIOCHEMICAL JOURNAL, 1999, 343 :443-452
[9]   Assembly of an A kinase-anchoring protein-β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling [J].
Fraser, IDC ;
Cong, M ;
Kim, J ;
Rollins, EN ;
Daaka, Y ;
Lefkowitz, RJ ;
Scott, JD .
CURRENT BIOLOGY, 2000, 10 (07) :409-412
[10]  
Gomez LL, 2002, J NEUROSCI, V22, P7027