Type III secretion systems and pathogenicity islands

被引：49

作者：

Winstanley, C ^{[1
]}

Hart, CA ^{[1
]}

机构：

[1] Univ Liverpool, Dept Med Microbiol & Genitourinary Med, Liverpool L69 3GA, Merseyside, England

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2001年 / 50卷 / 02期

关键词：

D O I：

10.1099/0022-1317-50-2-116

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Some bacterial pathogens have evolved by acquiring pathogenicity islands (PIs), which are clusters of genes encoding virulence traits, PIs encoding the secretion of effector molecules via type III secretion (TTS) systems have been discovered in several gramnegative pathogens. TTS systems are involved in contact-dependent secretion of virulence factors and can facilitate delivery of toxins directly into target cells, The expanding list of bacteria found to contain clusters of TTS genes includes members of the genera Yersinia, Salmonella, Shigella, Escherichia, Pseudomonas, Bordetella, Burkholderia, Chlamydia,din and a number of plant pathogens or symbionts. This review discusses the current knowledge of the role of TTS PIs in pathogenicity, the genetic organisation and evolution of such systems, and the potential for using TTS systems as targets for novel treatments.

引用

页码：116 / 126

页数：11

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