Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age

被引：24

作者：

Miyashita, Naoyuki ^{[1
]}

Maruyama, Takaya ^{[2
]}

Kobayashi, Tetsu ^{[2
]}

Kobayashi, Hiroyasu ^{[2
]}

Taguchi, Osamu ^{[2
]}

Kawai, Yasuhiro ^{[3
]}

Yamaguchi, Tetsuya ^{[3
]}

Ouchi, Kazunobu ^{[3
]}

Oka, Mikio ^{[1
]}

机构：

[1] Kawasaki Med Sch, Dept Resp Med, Okayama 7010192, Japan

[2] Mie Univ, Grad Sch Med, Dept Pulm & Crit Care Med, Tsu, Mie 514, Japan

[3] Kawasaki Med Sch, Dept Pediat, Kurashiki, Okayama, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2011年 / 17卷 / 01期

关键词：

Mycoplasma pneumoniae; Community-acquired pneumonia; Macrolide-resistant; REAL-TIME PCR; MOLECULAR ANALYSIS; STRAINS; FRANCE;

D O I：

10.1007/s10156-010-0093-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia. The pneumonia severity score of both patients was mild, and rapid clinical improvement was seen after administration of fluoroquinolone. Clinical features of macrolide-resistant M. pneumoniae pneumonia were identical to those of macrolide-sensitive M. pneumoniae pneumonia. An A-to-G transition at position 2063 and 2064, respectively, in domain V of the 23S rRNA gene was identified. The minimum inhibitory concentration of erythromycin of these isolates was greatly elevated. In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults.

引用

页码：114 / 118

页数：5

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