The role of L-arginine in hypertension and nephrotoxicity
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作者:
Klahr, S
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Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med, St Louis, MO 63110 USAWashington Univ, Sch Med, Barnes Jewish Hosp, Dept Med, St Louis, MO 63110 USA
Klahr, S
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机构:
[1] Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med, St Louis, MO 63110 USA
The L-arginine-nitric oxide pathway appears to play an important role in systemic hypertension, progressive renal disease, nephrotoxicity (lead poisoning), inflammation and atherosclerosis, interactions of nitric oxide with other systems (renin-angiotensin, endothelins, eicosanoids, cytokines and other regulators of inflammation) have been described. These interactions may be important in disease states. Curr Opin Nephrol Hypertens 7:547-550. (C) 1998 Lippincott Williams & Wilkins.