Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections

被引：397

作者：

Steenbergen, JN ^{[1
]}

Alder, J ^{[1
]}

Thorne, GM ^{[1
]}

Tally, FP ^{[1
]}

机构：

[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2005年 / 55卷 / 03期

关键词：

MRSA; cSSSI; vancomycin;

D O I：

10.1093/jac/dkh546

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI). Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections.

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收藏

页码：283 / 288

页数：6

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