Matrix Gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor

被引：89

作者：

Farzaneh-Far, A ^{[1
]}

Proudfoot, D ^{[1
]}

Weissberg, PL ^{[1
]}

Shanahan, CM ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 277卷 / 03期

关键词：

calcium; matrix Gla protein; vascular calcification; vascular smooth muscle cell; calcification; calcium-sensing receptor;

D O I：

10.1006/bbrc.2000.3747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Matrix Gla protein (MGP) is a mineral binding extracellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification. It is known to be upregulated in areas of extracellular calcification possibly to limit further harmful calcification. In this study we have demonstrated that extracellular ionic calcium (high levels of which induce calcification) is a key signal for MGP regulation and that this effect is mediated by a G protein mediated cation-sensing mechanism, functionally related to, but molecularly distinct from the calcium-sensing receptor. We therefore propose that this novel cation sensing mechanism may play a homeostatic role in preventing pathological calcification. (C) 2000 Academic Press.

引用

页码：736 / 740

页数：5

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