Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism

被引：208

作者：

Novacek, Gottfried ^{[1
]}

Weltermann, Ansgar ^{[2
]}

Sobala, Anna

Tilg, Herbert ^{[3
]}

Petritsch, Wolfgang ^{[4
]}

Reinisch, Walter

Mayer, Andreas ^{[5
]}

Haas, Thomas ^{[6
]}

Kaser, Arthur ^{[7
]}

Feichtenschlager, Thomas ^{[8
]}

Fuchssteiner, Harry ^{[9
]}

Knoflach, Peter ^{[11
]}

Vogelsang, Harald

Miehsler, Wolfgang

Platzer, Reingard ^{[10
]}

Tillinger, Wolfgang ^{[12
]}

Jaritz, Bernhard ^{[13
]}

Schmid, Alfons ^{[14
]}

Blaha, Benedikt ^{[15
]}

Dejaco, Clemens

Eichinger, Sabine ^{[16
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria

[2] Elisabethinen Hosp Linz, Dept Internal Med 1, Linz, Austria

[3] Acad Teaching Hosp Hall Tirol, Dept Med, Hall In Tirol, Austria

[4] Med Univ Graz, Dept Internal Med, Graz, Austria

[5] Gen Hosp St Polten, Dept Internal Med, St Polten, Austria

[6] Paracelsus Private Med Univ, Dept Internal Med 1, Salzburg, Austria

[7] Innsbruck Med Univ, Dept Internal Med 2, Innsbruck, Austria

[8] Hosp Rudolfstiftung, Dept Internal Med 4, Vienna, Austria

[9] Elisabethinen Hosp Linz, Dept Internal Med 4, Linz, Austria

[10] Wiener Neustadt Gen Hosp, Dept Internal Med 1, Wiener Neustadt, Austria

[11] Klinikum Wels, Dept Gastroenterol, Wels, Austria

[12] Gen Hosp Hietzing, Dept Internal Med 1, Vienna, Austria

[13] Landesklinikum Mistelbach Ganserndorf, Dept Internal Med 2, Mistelbach, Austria

[14] Danube Hosp, Dept Internal Med 2, Vienna, Austria

[15] Wilheminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria

[16] Med Univ Vienna, Dept Internal Med 1, A-1090 Vienna, Austria

来源：

GASTROENTEROLOGY | 2010年 / 139卷 / 03期

关键词：

Crohn's Disease; Ulcerative Colitis; Active Disease; Provoked Thrombosis; DEEP-VEIN THROMBOSIS; PULMONARY-EMBOLISM; ULCERATIVE-COLITIS; PROSPECTIVE-COHORT; END-POINTS; THERAPY; ANTICOAGULATION; METAANALYSIS; COAGULATION; MORTALITY;

D O I：

10.1053/j.gastro.2010.05.026

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) are at increased risk of a first venous thromboembolism (VTE), yet their risk of recurrent VTE is unknown. We performed a cohort study to determine the risk for recurrent VTE among patients with IBD compared with subjects without IBD. METHODS: We assessed 2811 patients with IBD for a history of VTE, recruited from outpatient clinics at 14 referral centers (June 2006-December 2008). Patients with VTE before a diagnosis of IBD or those not confirmed to have VTE, cancer, or a VTE other than deep vein thrombosis or pulmonary embolism, were excluded. Recurrence rates were compared with 1255 prospectively followed patients without IBD that had a first unprovoked VTE (not triggered by trauma, surgery, or pregnancy). The primary end point was symptomatic, objectively confirmed, recurrent VTE after discontinuation of anticoagulation therapy after a first VTE. RESULTS: Overall, of 116 IBD patients who had a history of first VTE, 86 were unprovoked. The probability of recurrence 5 years after discontinuation of anticoagulation therapy was higher among patients with IBD than patients without IBD (33.4%; 95% confidence interval [CI]: 21.8 -45.0 vs 21.7%; 95% CI: 18.8-24.6; P = .01). After adjustment for potential confounders, IBD was an independent risk factor of recurrence (hazard ratio = 2.5; 95% CI: 1.4-4.2; P = .001). CONCLUSIONS: Patients with IBD are at an increased risk of recurrent VTE compared to patients without IBD.

引用

页码：779 / U114

页数：10

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[1] Venous thromboembolism and cancer [J].