Disseminated tumour cells as a prognostic biomarker in colorectal cancer

被引：40

作者：

Flatmark, K. ^{[1
,2
]}

Borgen, E. ^{[3
]}

Nesland, J. M. ^{[3
,4
]}

Rasmussen, H. ^{[1
]}

Johannessen, H-O ^{[5
]}

Bukholm, I. ^{[6
]}

Rosales, R. ^{[7
]}

Harklau, L. ^{[8
]}

Jacobsen, H. J. ^{[9
]}

Sandstad, B. ^{[10
]}

Boye, K. ^{[1
,11
]}

Fodstad, O. ^{[1
,4
]}

机构：

[1] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Tumor Biol, N-0424 Oslo, Norway

[2] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Surg Oncol, N-0424 Oslo, Norway

[3] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Pathol, N-0424 Oslo, Norway

[4] Univ Oslo, Inst Clin Med, N-0424 Oslo, Norway

[5] Oslo Univ Hosp, Ulleval Univ Hosp, Dept Surg, N-0424 Oslo, Norway

[6] Akershus Univ Hosp, Dept Surg, N-1478 Lorenskog, Norway

[7] Asker & Baerum Hosp, Dept Surg, N-1336 Sandvika, Norway

[8] Oslo Univ Hosp, Aker Univ Hosp, Dept Surg, N-0424 Oslo, Norway

[9] Diakonhjemmet Hosp, Dept Surg, N-0319 Oslo, Norway

[10] Oslo Univ Hosp, Norwegian Radium Hosp, Clin Trials Unit, N-0424 Oslo, Norway

[11] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Oncol, N-0424 Oslo, Norway

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 09期

关键词：

disseminated tumour cells; colorectal cancer; EpCAM; cytokeratin; prognostic biomarker; BREAST-CANCER; MICROMETASTATIC CELLS; BONE-MARROW; EPCAM;

D O I：

10.1038/bjc.2011.97

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The study was performed to determine detection rate and prognostic relevance of disseminated tumour cells (DTC) in patients receiving curatively intended surgery for colorectal cancer (CRC). METHODS: The study population consisted of 235 patients with CRC prospectively recruited from five hospitals in the Oslo region. Bone marrow (BM) aspirates were collected at the time of surgery and the presence of DTC was determined by two immunological methods; immunomagnetic selection (using an anti-EpCAM antibody) and immunocytochemistry (using a pan-cytokeratin antibody). Associations between the presence of DTC and metastasis-free, disease-specific and overall survival were analysed using univariate and multivariate methods. RESULTS: Disseminated tumour cells were detected in 41 (17%) and 28 (12%) of the 235 examined BM samples by immunomagnetic selection and immunocytochemistry, respectively, with only five samples being positive with both methods. The presence of DTC was associated with adverse outcome (metastasis-free, disease-specific and overall survival) in univariate and multivariate analyses. CONCLUSION: The presence of DTC was associated with adverse prognosis in this cohort of patients curatively resected for CRC, suggesting that DTC detection still holds promise as a biomarker in CRC. British Journal of Cancer (2011) 104, 1434-1439. doi:10.1038/bjc.2011.97 www.bjcancer.com Published online 29 March 2011 (C) 2011 Cancer Research UK

引用

页码：1434 / 1439

页数：6

共 15 条

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