Adipose tissue dysfunction and impaired metabolic health in human obesity: a matter of oxygen?

被引：111

作者：

Goossens, Gijs H. ^{[1
]}

Blaak, Ellen E. ^{[1
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Human Biol, NUTRIM Sch Nutr & Translat Res Metab, NL-6200 MD Maastricht, Netherlands

来源：

FRONTIERS IN ENDOCRINOLOGY | 2015年 / 6卷

关键词：

adipose tissue; oxygentension; obesity; hypoxia; hyperoxia; bloodflow; metabolism; inflammation; IMPROVES INSULIN SENSITIVITY; OBSTRUCTIVE SLEEP-APNEA; ADIPOKINE EXPRESSION; HUMAN ADIPOCYTES; GENE-EXPRESSION; BLOOD-FLOW; 10; NIGHTS; HYPOXIA; INFLAMMATION; RESISTANCE;

D O I：

10.3389/fendo.2015.00055

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

[No abstract available]

引用

收藏

页数：5

相关论文

共 47 条

[1]

Adipose tissue, inflammation, and cardiovascular disease [J].

Berg, AH ;

Scherer, PE .

CIRCULATION RESEARCH, 2005, 96 (09) :939-949

[2]

Adipose tissue dysfunction contributes to obesity related metabolic diseases [J].

Blueher, Matthias .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 27 (02) :163-177

[3]

Oxygen, a source of life and stress [J].

Brahimi-Horn, M. Christiane ;

Pouyssegur, Jacques .

FEBS LETTERS, 2007, 581 (19) :3582-3591

[4]

Molecular mediators of hepatic steatosis and liver injury [J].

Browning, JD ;

Horton, JD .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (02) :147-152

[5]

Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes [J].

Chen, BY ;

Lam, KSL ;

Wang, Y ;

Wu, DH ;

Lam, MC ;

Shen, JG ;

Wong, LC ;

Hoo, RLC ;

Zhang, JL ;

Xu, AM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 341 (02) :549-556

[6]

Hypoxia reduces the response of human adipocytes towards TNFα resulting in reduced NF-κB signaling and MCP-1 secretion [J].

Famulla, S. ;

Horrighs, A. ;

Cramer, A. ;

Sell, H. ;

Eckel, J. .

INTERNATIONAL JOURNAL OF OBESITY, 2012, 36 (07) :986-992

[7]

Differentiation of human adipocytes at physiological oxygen levels results in increased adiponectin secretion and isoproterenol-stimulated lipolysis [J].

Famulla, Susanne ;

Schlich, Raphaela ;

Sell, Henrike ;

Eckel, Jurgen .

ADIPOCYTE, 2012, 1 (03) :132-141

[8]

Identification of Hypoxia-Induced Genes in Human SGBS Adipocytes by Microarray Analysis [J].

Geiger, Kathrin ;

Leiherer, Andreas ;

Muendlein, Axel ;

Stark, Nicole ;

Geller-Rhomberg, Simone ;

Saely, Christoph H. ;

Wabitsch, Martin ;

Fraunberger, Peter ;

Drexel, Heinz .

PLOS ONE, 2011, 6 (10)

[9]

Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans [J].

Goossens, GH ;

McQuaid, SE ;

Dennis, AL ;

van Baak, MA ;

Blaak, EE ;

Frayn, KN ;

Saris, WHM ;

Karpe, F .

JOURNAL OF PHYSIOLOGY-LONDON, 2006, 571 (02) :451-460

[10]

Goossens GH, 2013, DIABETES CARE, V36, pe197

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