Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa

被引：102

作者：

Davies, Todd A. ^{[1
]}

Shang, Wenchi ^{[1
]}

Bush, Karen ^{[1
]}

Flamm, Robert K. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ 08869 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期

关键词：

D O I：

10.1128/AAC.01529-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.

引用

页码：1510 / 1512

页数：3

共 12 条

[1]

[Anonymous], 2006, METH DIL ANT SUSC TE

[2]

Bonfiglio G, 2002, EXPERT OPIN INV DRUG, V11, P529

[3] Comparative in vitro antimicrobial activity of a new carbapenem, doripenem:: tentative disc diffusion criteria and quality control [J].

Brown, SD ;

Traczewski, MM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (06) :944-949

[4] COMPETITION OF BETA-LACTAM ANTIBIOTICS FOR THE PENICILLIN-BINDING PROTEINS OF PSEUDOMONAS-AERUGINOSA, ENTEROBACTER-CLOACAE, KLEBSIELLA-AEROGENES, PROTEUS-RETTGERI, AND ESCHERICHIA-COLI - COMPARISON WITH ANTIBACTERIAL ACTIVITY AND EFFECTS UPON BACTERIAL MORPHOLOGY [J].

CURTIS, NAC ;

ORR, D ;

ROSS, GW ;

BOULTON, MG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (03) :325-328

[5] In vitro antimicrobial activity of doripenem, a new carbapenem [J].

Ge, YG ;

Wikler, MA ;

Sahm, DF ;

Blosser-Middleton, RS ;

Karlowsky, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1384-1396

[6] PENICILLIN-BINDING PROTEINS AND BACTERIAL-RESISTANCE TO BETA-LACTAMS [J].

GEORGOPAPADAKOU, NH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (10) :2045-2053

[7] BINDING OF MONOBACTAMS TO PENICILLIN-BINDING PROTEINS OF ESCHERICHIA-COLI AND STAPHYLOCOCCUS-AUREUS - RELATION TO ANTI-BACTERIAL ACTIVITY [J].

GEORGOPAPADAKOU, NH ;

SMITH, SA ;

CIMARUSTI, CM ;

SYKES, RB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (01) :98-104

[8] MODE OF ACTION OF CEFTAZIDIME - AFFINITY FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA-COLI-K12, PSEUDOMONAS-AERUGINOSA AND STAPHYLOCOCCUS-AUREUS [J].

HAYES, MV ;

ORR, DC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 12 (02) :119-126

[9] Activities of doripenem (S-4661) against drug-resistant clinical pathogens [J].

Jones, RN ;

Huynh, HK ;

Biedenbach, DJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (08) :3136-3140

[10] In vitro selection of one-step mutants of Streptococcus pneumoniae resistant to different oral beta-lactam antibiotics is associated with alterations of PBP2x [J].

Sifaoui, F ;

Kitzis, MD ;

Gutmann, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (01) :152-156

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