AngiomiRs: MicroRNAs driving angiogenesis in cancer

被引:47
作者
Salinas-Vera, Yarely M. [1 ]
Marchat, Laurence A. [2 ]
Gallardo-Rincon, Dolores [3 ]
Ruiz-Garcia, Erika [3 ]
Astudillo-De la Vega, Horacio [4 ]
Echavarria-Zepeda, Raquel [5 ]
Lopez-Camarillo, Cesar [1 ]
机构
[1] Univ Autonoma Ciudad de Mexico, Posgrad Ciencias Genom, San Lorenzo 290, Ciudad De Mexico 03100, Mexico
[2] Inst Politecn Nacl, Programa Biomed Mol & Red Biotecnol, Ciudad De Mexico 07320, Mexico
[3] Inst Nacl Cancerol, Lab Med Translac, Ciudad De Mexico 14080, Mexico
[4] Hosp Oncol, Ctr Med Nacl Siglo XXI, Lab Invest Translac Canc & Terapia Celular, Ciudad De Mexico 06720, Mexico
[5] Inst Politecn Nacl, CONACYT, Ciudad De Mexico 11350, Mexico
关键词
cancer; microRNAs; angiogenesis; tumor neovascu-larization; therapy; CELL LUNG-CANCER; PANCREATIC DUCTAL ADENOCARCINOMA; PROMOTES TUMOR ANGIOGENESIS; ENDOTHELIAL GROWTH-FACTOR; COLORECTAL-CANCER; DOWN-REGULATION; SUPPRESSES ANGIOGENESIS; BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; MOLECULAR PATHWAYS;
D O I
10.3892/ijmm.2018.4003
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
100103 [病原生物学]; 100218 [急诊医学];
摘要
Angiogenesis is an important hallmark of cancer serving a key role in tumor growth and metastasis. Therefore, tumor angiogenesis has become an attractive target for development of novel drug therapies. An increased amount of anti-angiogenic compounds is currently in preclinical and clinical development for personalized therapies. However, resistance to current angiogenesis inhibitors is emerging, indicating that there is a need to identify novel anti-angiogenic agents. In the last decade, the field of microRNA biology has exploded revealing unsuspected functions in tumor angiogenesis. These small non-coding RNAs, which have been dubbed as angiomiRs, may target regulatory molecules driving angiogenesis, such as cytokines, metalloproteinases and growth factors, including vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factor, epidermal growth factor, hypoxia inducible factor-1, as well as mitogen-activated protein kinase, phosphoinositide 3-kinase and transforming growth factor signaling pathways. The present review discusses the current progress towards understanding the functions of miRNAs in tumor angiogenesis regulation in diverse types of human cancer. Furthermore, the potential clinical application of angiomiRs towards anti-angiogenic tumor therapy was explored.
引用
收藏
页码:657 / 670
页数:14
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