Cerebrovascular damage as a cause for Alzheimer's disease

被引：58

作者：

Humpel, C ^{[1
]}

Marksteiner, J ^{[1
]}

机构：

[1] Innsbruck Med Univ, Lab Exp Alzhemiers Res, Dept Psychiat, Lab Psychiat, A-6020 Innsbruck, Austria

来源：

CURRENT NEUROVASCULAR RESEARCH | 2005年 / 2卷 / 04期

关键词：

vascular system; Alzheimer; vascular dementia; hypothesis; cascade;

D O I：

10.2174/156720205774322610

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease is a progressive brain disorder that gradually destroys a patient's memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimer's disease is initiated by amyloid beta-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimer's disease. Recent studies revealed a significant comorbidity of Alzheimer's disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimer's disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.

引用

收藏

页码：341 / 347

页数：7

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