共 22 条
Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency
被引:69
作者:

Newton, K
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机构: Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

French, DM
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h-index: 0
机构: Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

Yan, MH
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h-index: 0
机构: Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

Frantz, GD
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h-index: 0
机构: Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

Dixit, VM
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机构: Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
机构:
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
关键词:
D O I:
10.1128/MCB.24.4.1608-1613.2004
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
EDA-A1 and EDA-A2 are members of the tumor necrosis factor family of ligands. The products of alternative splicing of the ectodysplasin (EDA) gene, EDA-A1 and EDA-A2 differ by an insertion of two amino acids and bind to distinct receptors. The longer isoform, EDA-A1, binds to EDAR and plays an important role in sweat gland, hair, and tooth development; mutations in EDA, EDAR, or the downstream adaptor EDARADD cause hypohidrotic ectodermal dysplasia. EDA-A2 engages the receptor XEDAR, but its role in the whole organism is less clear. We have generated XEDAR-deficient mice by gene targeting and transgenic mice expressing secreted forms of EDA-A1 or EDA-A2 downstream of the skeletal muscle-specific myosin light-chain 2 or skin-specific keratin 5 promoter. Mice lacking XEDAR were indistinguishable from their wild-type littermates, but EDA-A2 transgenic mice exhibited multifocal myodegeneration. This phenotype was not observed in the absence of XEDAR. Skeletal muscle in EDA-A1 transgenic mice was unaffected, but their sebaceous glands were hypertrophied and hyperplastic, consistent with a role for EDA-A1 in the development of these structures. These data indicate that XEDAR-transduced signals are dispensable for development of ectoderm-derived organs but might play a role in skeletal muscle homeostasis.
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页码:1608 / 1613
页数:6
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