Mechanisms of Allergic Sensitization to Foods: Bypassing Immune Tolerance Pathways

被引：12

作者：

Berin, M. Cecilia ^{[1
]}

机构：

[1] Mt Sinai Sch Med, New York, NY 10029 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2012年 / 32卷 / 01期

关键词：

Oral tolerance; Dendritic cell; Adjuvant; Epicutaneous; Innate immunity; iT(reg); MYELIN BASIC-PROTEIN; SUPPRESSOR T-CELLS; GROWTH-FACTOR-BETA; FREE MOUSE MODEL; DENDRITIC CELLS; ORAL TOLERANCE; ANAPHYLAXIS; INDUCTION; RESPONSES; PEANUT;

D O I：

10.1016/j.iac.2011.10.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The default response of the mucosal immune system to antigens derived from food is one of active immune tolerance carried out by regulatory T cells and induced by dendritic cells residing in the intestinal mucosa. This tolerance response must be inhibited or bypassed to generate allergic sensitization in experimental food allergy and this has been achieved by 3 main approaches: genetic modifications, experimental adjuvants, and bypassing oral tolerance by administering the antigen through alternative routes. This article discusses the implications of these approaches for understanding the mechanisms of sensitization to food allergens in human disease.

引用

收藏

页码：1 / +

页数：11

相关论文

共 64 条

[1] In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin [J].

Anjuère, F ;

Luci, C ;

Lebens, M ;

Rousseau, D ;

Hervouet, C ;

Milon, G ;

Holmgren, J ;

Ardavin, C ;

Czerkinsky, C .

JOURNAL OF IMMUNOLOGY, 2004, 173 (08) :5103-5111

[2] An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut [J].

Birmingham, Neil Patrick ;

Parvataneni, Sitaram ;

Hassan, Hanem M. Ahmed ;

Harkema, Jack ;

Samineni, Sridhar ;

Navuluri, Lalitha ;

Kelly, Caleb James ;

Gangur, Venu .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2007, 144 (03) :203-210

[3] Gastrointestinal dendritic cells promote Th2 skewing via OX40L [J].

Blazquez, Ana Belen ;

Berin, M. Cecilia .

JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :4441-4450

[4] Origin of the Lamina Propria Dendritic Cell Network [J].

Bogunovic, Milena ;

Ginhoux, Florent ;

Helft, Julie ;

Shang, Limin ;

Hashimoto, Daigo ;

Greter, Melanie ;

Liu, Kang ;

Jakubzick, Claudia ;

Ingersoll, Molly A. ;

Leboeuf, Marylene ;

Stanley, E. Richard ;

Nussenzweig, Michel ;

Lira, Sergio A. ;

Randolph, Gwendalyn J. ;

Merad, Miriam .

IMMUNITY, 2009, 31 (03) :513-525

[5] Oral sensitization with shrimp tropomyosin induces in mice allergen-specific IgE, T cell response and systemic anaphylactic reactions [J].

Capobianco, Francescamaria ;

Butteroni, Cinzia ;

Barletta, Bianca ;

Corinti, Silvia ;

Afferni, Claudia ;

Tinghino, Raffaella ;

Boirivant, Monica ;

Di Felice, Gabriella .

INTERNATIONAL IMMUNOLOGY, 2008, 20 (08) :1077-1086

[6] Role of bacterial superantigens in atopic dermatitis: Implications for future therapeutic strategies [J].

Cardona, Ivan D. ;

Cho, Sang Hyun ;

Leung, Donald Y. M. .

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2006, 7 (05) :273-279

[7]

CHASE MW, 1946, P SOC EXP BIOL MED, V61, P257

[8] REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS [J].

CHEN, YH ;

KUCHROO, VK ;

INOBE, J ;

HAFLER, DA ;

WEINER, HL .

SCIENCE, 1994, 265 (5176) :1237-1240

[9]

CHEN YH, 1995, J IMMUNOL, V155, P910

[10] PERIPHERAL DELETION OF ANTIGEN-REACTIVE T-CELLS IN ORAL TOLERANCE [J].

CHEN, YH ;

INOBE, J ;

MARKS, R ;

GONNELLA, P ;

KUCHROO, VK ;

WEINER, HL .

NATURE, 1995, 376 (6536) :177-180

← 1 2 3 4 5 6 7 →