Synthesis of a model DEF-ring core of hexacyclinic acid

被引:28
作者
Clarke, PA
Grist, M
Ebden, M
Wilson, C
机构
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] AstraZeneca R&D, Med Chem, Loughborough LE11 5RH, Leics, England
关键词
D O I
10.1039/b303706a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The first synthesis of a DEF-ring system of hexacyclinic acid is reported. The key steps being an intramolecular Pd(0) pi-pallyl substitution reaction, followed by a transannular iodocyclisation with acetyl hypoiodite.
引用
收藏
页码:1560 / 1561
页数:2
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