Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit

被引：23

作者：

Fukutomi, R

Tanatani, A

Kakuta, H

Tomioka, N

Itai, A

Hashimoto, Y

Shudo, K

Kagechika, H

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[3] Inst Med Mol Design, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(98)01378-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetraguanidines (1 and 2) with an aromatic multilayered structure exhibit potent binding to a specific site of DNAs with binding constants of the order of 10(7) M-1 as deduced from Scatchard analysis of ultrafiltration data and simulation of CD titration curves. NMR spectra of the complexes indicated that 1 and 2 bind DNAs sequence-specifically at the minor groove, as predicted by computational docking studies. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6475 / 6478

页数：4

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