Occludin: Structure, function and regulation

被引：387

作者：

Feldman, GJ

Mullin, JM

Ryan, MP ^{[1
]}

机构：

[1] Univ Coll Dublin, Dept Pharmacol, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

[2] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 06期

关键词：

occludin; tight junction; ZO-1; claudin; phosphorylation; GTPases; proteases; cytokines; cancer; inflammatory diseases;

D O I：

10.1016/j.addr.2005.01.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is all essential component of these barriers. Occludin is a major component of the TJ. The Structure of occludin, including its gene splice variants and protein essential components have been elucidated. Phosphorylation/dephosphorylation plays a major role in regulation of occludin and TJ. Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target. (c) 2005 Published by Elsevier B.V.

引用

页码：883 / 917

页数：35

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