Tie receptors: New modulators of angiogenic and lymphangiogenic responses

被引：307

作者：

Jones, N

Iljin, K

Dumont, DJ

Alitalo, K

机构：

[1] Univ Helsinki, Biomedicum Inst, Ludwig Inst Canc Res, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

[2] Univ Toronto, Sunnybrook & Womens Coll Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 04期

关键词：

D O I：

10.1038/35067005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer; diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress - processes that are important not only during development but throughout an organism's life.

引用

页码：257 / 267

页数：11

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