Human neural stem cells improve cognitive function of aged brain

被引：126

作者：

Qu, T ^{[1
]}

Brannen, CL ^{[1
]}

Kim, HM ^{[1
]}

Sugaya, K ^{[1
]}

机构：

[1] Univ Illinois, Inst Psychiat, Dept Psychiat, Chicago, IL 60612 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 06期

关键词：

aging; differentiation; engraftment; memory; migration; progenitor; transplantation;

D O I：

10.1097/00001756-200105080-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The capability for in vitro expansion of human neural stem cells (HNSCs) provides a well characterized and unlimited source alternative to using primary fetal tissue for neuronal replacement therapies. The HNSCs, injected into the lateral ventricle of 24-month-old rats after in vitro expansion, displayed extensive and positional incorporation into the aged host brain with improvement of cognitive score assessed by the Morris water maze after 4 weeks of the transplantation. Our results demonstrate that the aged brain is capable of providing the necessary environment for HNSCs to retain their pluripotent status and suggest the potential for neuroreplacement therapies in age-associated neurodegenerative disease. NeuroReport 12:1127-1132 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1127 / 1132

页数：6

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