MAP kinase modules: Many roads home

被引:90
作者
Raman, M [1 ]
Cobb, MH [1 ]
机构
[1] Univ Texas, SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA
关键词
D O I
10.1016/j.cub.2003.10.053
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
All known MAP kinase cascades have a simple three tier linear architecture; yet despite their diverse range of inputs, they provide exquisitely precise and sensitive responses. Recent studies have shown that differential use of pathway components enhances pathway specificity, facilitates signal integration and confers output selectivity.
引用
收藏
页码:R886 / R888
页数:3
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