Correlation of intraocular pressure and central corneal thickness in normal myopic eyes and after laser in situ keratomileusis

Purpose: To determine the relationship of intraocular pressure (IOP) and central corneal thickness (CCT) in normal myopic eyes and after laser in situ keratomileusis (LASIK). Setting: TLC The Windsor Laser Center, Windsor, Ontario, Canada, Methods: Intraocular pressure measured by Goldmann applanation tonometry and CCT by ultrasonic pachymetry were determined in a group of untreated corneas of 120 patients (203 eyes) and in 50 patients (85 eyes) pre- and post-LASIK. Statistical analyses were performed with the Pearson correlation coefficient and paired Student t test. Results: In the untreated group or 288 eyes, mean CCT was 544.0 mu m +/- 37.3 (SD) (range 461 to 664 mu m) and mean IOP, 15.6 +/- 2.7 nm Hg (range 10 to 24 mm Hg). The correlation between IOP and CCT in this group was highly significant (r = 0.44 P < .0001). The slope was 0.032 mm Hg/mu m of CCT or an approximate decrease of 1 mm Hg, for a reduction in CCT of 31.3 mu m. In the post-LASIK group, mean CCT dropped approximately 73.0 mu m to 479.5 +/- 41.2 mu m (range 408 to 503 mu m) and IOP dropped to a mean of 13.6 +/- 3.3 mm Hg (range 7 to 22 mm Hg). A significant correlation was round between IOP and CCT after LASIK (r = 0.33; P < .002). The difference between the mean pre- and post-LASIK measurements of applanation IOP was 2.5 mm Hg, which was significant (P < .0001). The post-LASIK slope was 0.027 mm Hg/mu m, or a decrease of 1.0 mm Hg per 37.8 mu m reduction in CCT. Conclusion: Central corneal thickness is an important variable in the evaluation of applanation IOP and should be included in the assessment of any Case of potential glaucoma or ocular hypertension, particularly in eyes with previous photoablative refractive surgery.