A free-running DNA motor powered by a nicking enzyme

被引:260
作者
Bath, J [1 ]
Green, SJ [1 ]
Turberfield, AJ [1 ]
机构
[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England
基金
英国工程与自然科学研究理事会;
关键词
DNA; enzymes; molecular devices; nanostructures; self-assembly;
D O I
10.1002/anie.200501262
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) DNA burns its bridges: A unidirectional molecular motor that moves an oligonucleotide cargo along a self-assembled track is powered by restriction endonuclease hydrolysis of the phosphodiester backbone (see scheme). Damage caused to the track by the restriction enzyme prevents the cargo from stepping backwards and therefore imposes directionality. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:4358 / 4361
页数:4
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