A free-running DNA motor powered by a nicking enzyme

被引：260

作者：

Bath, J ^{[1
]}

Green, SJ ^{[1
]}

Turberfield, AJ ^{[1
]}

机构：

[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 28期

基金：

英国工程与自然科学研究理事会;

关键词：

DNA; enzymes; molecular devices; nanostructures; self-assembly;

D O I：

10.1002/anie.200501262

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) DNA burns its bridges: A unidirectional molecular motor that moves an oligonucleotide cargo along a self-assembled track is powered by restriction endonuclease hydrolysis of the phosphodiester backbone (see scheme). Damage caused to the track by the restriction enzyme prevents the cargo from stepping backwards and therefore imposes directionality. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4358 / 4361

页数：4

共 20 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine
Alberti, P
Mergny, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) : 1569 - 1573
[2] Cleavage of individual DNA strands by the different subunits of the heterodimeric restriction endonuclease BbvCI
Bellamy, SRW
Milsom, SE
Scott, DJ
Daniels, LE
Wilson, GG
Halford, SE
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2005, 348 (03) : 641 - 653
[3] An autonomous DNA nanomotor powered by a DNA enzyme
Chen, Y
Wang, MS
Mao, CD
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (27) : 3554 - 3557
[4] SINGLE MYOSIN MOLECULE MECHANICS - PICONEWTON FORCES AND NANOMETER STEPS
FINER, JT
SIMMONS, RM
SPUDICH, JA
[J]. NATURE, 1994, 368 (6467) : 113 - 119
[5] Site-specific DNA-nicking mutants of the heterodimeric restriction endonuclease R.BbvCI
Heiter, DF
Lunnen, KD
Wilson, GG
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2005, 348 (03) : 631 - 640
[6] Li JWJ, 2002, NANO LETT, V2, P315, DOI [10.1021/nl015713+, 10.1021/n1015713+]
[7] Directed particle diffusion under "burnt bridges" conditions
Mai, J
Sokolov, IM
Blumen, A
[J]. PHYSICAL REVIEW E, 2001, 64 (01): : 4
[8] A nanomechanical device based on the B-Z transition of DNA
Mao, CD
Sun, WQ
Shen, ZY
Seeman, NC
[J]. NATURE, 1999, 397 (6715) : 144 - 146
[9] SENSITIVE FLUORESCENCE-BASED THERMODYNAMIC AND KINETIC MEASUREMENTS OF DNA HYBRIDIZATION IN SOLUTION
MORRISON, LE
STOLS, LM
[J]. BIOCHEMISTRY, 1993, 32 (12) : 3095 - 3104
[10] The kinetics of oligonucleotide replacements
Reynaldo, LP
Vologodskii, AV
Neri, BP
Lyamichev, VI
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 297 (02) : 511 - 520

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