Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

被引:351
作者
Chou, Hsin-Hung [1 ]
Chiu, Hsuan-Chao [2 ]
Delaney, Nigel F. [1 ]
Segre, Daniel [2 ,3 ,4 ]
Marx, Christopher J. [1 ,5 ]
机构
[1] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
[2] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA
[3] Boston Univ, Dept Biol, Boston, MA 02215 USA
[4] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[5] Harvard Univ, Ctr Syst Biol, Fac Arts & Sci, Cambridge, MA 02138 USA
基金
美国国家科学基金会;
关键词
ESCHERICHIA-COLI; EVOLUTION; FITNESS; ARCHITECTURE; LANDSCAPE; DYNAMICS; PROTEIN;
D O I
10.1126/science.1203799
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We generated combinations of beneficial mutations that arose in a lineage during rapid adaptation of a bacterium whose growth depended on a newly introduced metabolic pathway. The proportional selective benefit for three of the four loci consistently decreased when they were introduced onto more fit backgrounds. These three alleles all reduced morphological defects caused by expression of the foreign pathway. A simple theoretical model segregating the apparent contribution of individual alleles to benefits and costs effectively predicted the interactions between them. These results provide the first evidence that patterns of epistasis may differ for within- and between-gene interactions during adaptation and that diminishing returns epistasis contributes to the consistent observation of decelerating fitness gains during adaptation.
引用
收藏
页码:1190 / 1192
页数:3
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