Secreting tumor suppression

被引：7

作者：

Chien, Yuchen ^{[1
]}

Lowe, Scott W. ^{[1
,2
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

来源：

CELL | 2008年 / 132卷 / 03期

关键词：

D O I：

10.1016/j.cell.2008.01.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.

引用

页码：339 / 341

页数：3

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