Mechanisms of immune evasion of human neuroblastoma

被引：67

作者：

Raffaghello, L ^{[1
]}

Prigione, I

Airoldi, I

Camoriano, M

Morandi, F

Bocca, P

Gambini, C

Ferrone, S

Pistoia, V

机构：

[1] G Gaslini Inst Children, Lab Oncol, Genoa, Italy

[2] Ist Giannina Gaslini, Pathol Lab, I-16148 Genoa, Italy

[3] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

来源：

CANCER LETTERS | 2005年 / 228卷 / 1-2期

关键词：

neuroblastoma; immunotherapy; NK cells;

D O I：

10.1016/j.canlet.2004.11.064

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroblastoma (NB) is a common neuroectodermal tumor of childhood with low response to conventional therapy in patients with advanced stage disease. Among novel strategies, immumotherapy has attracted much interest. However, scanty information is available about the immunogenicity of human NB. Here, we review our data showing that human NB may evade the control mediated by T cytotoxic lymphocytes and natural killer (NK) cells through multiple mechanisms: (i) downregulation of HLA class I molecules and antigen processing machinery components (ii) downregulation of activating ligands for the activating immunoreceptor NKG2D expressed by cytotoxic T lymphocytes and NK cells. Additional mechanisms of immune evasion used by human NB cells are discussed. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：155 / 161

页数：7

共 21 条

[1]

AIROLDI S, 2003, BRIT J CANCER, V19, P1527

[2] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].