The mimetics of antiadhesive peptides as the inhibitors of Mycibacterium kansasii phagocytosis

被引：7

作者：

Siemion, IZ

Gawlowska, M

Slepokura, K

Biernat, M

Wieczorek, Z

机构：

[1] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

[2] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-50114 Wroclaw, Poland

来源：

PEPTIDES | 2005年 / 26卷 / 09期

关键词：

antiadhesive peptides; peptide mimetics; Mycobacteria phagocytosis; guanidino acids;

D O I：

10.1016/j.peptides.2005.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The alpha-guanidino acids derived of 15 proteinaceous amino acids, omega-guanidino acids with gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the mimetics of antiadhesive peptides in Mycobacteria phagocytosis inhibition. The crystal structure of omega-guanidino acids used was determined by X-ray structural analysis. It follows from our experiments that the proper distance between Guanidine and carboxyl groups of effector molecules is of decisive importance for their inhibitory activity. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1543 / 1549

页数：7

共 27 条

[1]

LOW-MOLECULAR-WEIGHT, NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS [J].