Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal

被引：18

作者：

Wang, Xiusong ^{[1
,2
,3
,4
]}

Liu, Yadong ^{[5
]}

Lei, Yanlin ^{[1
,2
,4
]}

Zhou, Dongming ^{[4
,6
]}

Fu, Yu ^{[1
,2
,4
]}

Che, Yi ^{[1
,2
,4
,7
]}

Xu, Ruchang ^{[8
]}

Yu, Hualin ^{[5
]}

Hu, Xintian ^{[2
,3
,9
]}

Ma, Yuanye ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Zool, Lab Primate Neurosci Res, Kunming 650223, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Lab Sensory Motor Integrat Res, Kunming 650223, Yunnan, Peoples R China

[4] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Kunming Med Sch, Affiliated Hosp 1, Dept Neurosurg, Kunming 650032, Yunnan, Peoples R China

[6] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

[7] Suzhou Univ, Sch Life Sci, Suzhou 215006, Jiangsu, Peoples R China

[8] Kunming Med Sch, Affiliated Hosp 2, Dept Endocrine, Kunming 650101, Yunnan, Peoples R China

[9] E China Normal Univ, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2008年 / 433卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D2; receptors; electromagnetic field; immunohistochemistry; dorsal hippocampus; morphine; rats;

D O I：

10.1016/j.neulet.2008.01.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The aim of this study was to investigate the effect of extremely low-frequency electromagnetic field (ELF-EMF) exposure during morphine treatment on dopamine D2 receptor (D2R) density in the rat dorsal hippocampus following withdrawal. Rats were exposed to ELF-EMF (20 Hz, 14 mT) or sham exposed for 1 h per day before injection of morphine (10 mg/kg, i.p.) once daily for 12 days. The saline control group was sham exposed for the same period. Immunohistochemistry was used to detect the density of D2Rs on the 1st, 3rd and 5th morphine withdrawal days. The results showed that the density of D2Rs in sham-exposed morphine-treated rats on the 1st and 3rd days of morphine withdrawal was significantly lower than that of the saline control group. The ELF-EMF-exposed morphine group also exhibited a significantly lower density of D2Rs on the 1st and 3rd withdrawal days relative to the sham-exposed morphine group. However, the D2R density in both groups tended to recover as morphine withdrawal days increased. The results suggest that dorsal hippocampal D2Rs are sensitive to morphine withdrawal and that this is potentiated by ELF-EMF pre-exposure during morphine treatment. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：178 / 182

页数：5

共 37 条

[1]

Cieslar G., 1994, BALNEOL POL, V36, P24

[2]

CONDITIONED PLACE PREFERENCE PRODUCED BY INTRA-HIPPOCAMPAL MORPHINE [J].