Reactive oxygen species and HIF-1 signalling in cancer

被引：230

作者：

Galanis, Alex ^{[1
]}

Pappa, Aglaia ^{[1
]}

Giannakakis, Antonis ^{[1
]}

Lanitis, Evripidis ^{[1
]}

Dangaj, Denarda ^{[1
]}

Sandaltzopoulos, Raphael ^{[1
]}

机构：

[1] Democritus Univ Thrace, Dept Mol Biol & Genet, Lab Gene Express Mol Diag & Modern Therapeut, Alexandroupolis 68100, Greece

来源：

CANCER LETTERS | 2008年 / 266卷 / 01期

关键词：

HIF-1; signalling; reactive oxygen species; cancer; ERK/MEK; PI3K; PKB/Akt; mTOR; protein hydroxylation;

D O I：

10.1016/j.canlet.2008.02.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：12 / 20

页数：9

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