High rate of tuberculosis reinfection during a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis strain B

被引:78
作者
Rivero, A
Márquez, M
Santos, J
Pinedo, A
Sánchez, MA
Esteve, A
Samper, S
Martin, C
机构
[1] Hosp Univ Reina Sofia, Serv Enfermedades Infecc, Dept Infect Dis, Cordoba 14004, Spain
[2] Virgen de la Victoria Univ Hosp Malaga, Dept Microbiol, Malaga, Spain
[3] Univ Zaragoza, Dept Microbiol & Publ Hlth, Zaragoza, Spain
[4] Virgen de la Victoria Univ Hosp Malaga, Infect Dis Unit, Malaga, Spain
关键词
D O I
10.1086/317547
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We present a study of a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis in 31 patients, 30 of whom were infected with human immunodeficiency virus; all 31 died of progressive tuberculosis. All M. bovis strains had identical spoligotyping patterns and showed resistance to 12 antituberculosis drugs. Reinfection was suggested in 11 cases and confirmed in 4 by molecular typing methods. The causative strain was named "B strain."
引用
收藏
页码:159 / 161
页数:3
相关论文
共 7 条
[1]  
FAIRSHTER RD, 1975, AM REV RESPIR DIS, V112, P37
[2]   Nosocomial transmission of Mycobacterium bovis resistant to 11 drugs in people with advanced HIV-1 infection [J].
Guerrero, A ;
Cobo, J ;
Fortun, J ;
Navas, E ;
Quereda, C ;
Asensio, A ;
Canon, J ;
Blazquez, J ;
GomezMampaso, E .
LANCET, 1997, 350 (9093) :1738-1742
[3]   SUPERINFECTION WITH RIFAMPIN-ISONIAZID-STREPTOMYCIN-ETHAMBUTOL (RISE)-RESISTANT TUBERCULOSIS IN 3 PATIENTS WITH AIDS - CONFIRMATION BY POLYMERASE CHAIN-REACTION FINGERPRINTING [J].
HORN, DL ;
HEWLETT, D ;
HAAS, WH ;
BUTLER, WR ;
ALFALLA, C ;
TAN, E ;
LEVINE, A ;
NAYAK, A ;
OPAL, SM .
ANNALS OF INTERNAL MEDICINE, 1994, 121 (02) :115-116
[4]   EXOGENOUS REINFECTION WITH TUBERCULOSIS IN A SHELTER FOR THE HOMELESS [J].
NARDELL, E ;
MCINNIS, B ;
THOMAS, B ;
WEIDHAAS, S .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (25) :1570-1575
[5]   Transmission between HIV-infected patients of multidrug-resistant tuberculosis caused by Mycobacterium bovis [J].
Samper, S ;
Martin, C ;
Pinedo, A ;
Rivero, A ;
Blazquez, J ;
Baquero, F ;
vanSoolingen, D ;
vanEmbden, J .
AIDS, 1997, 11 (10) :1237-1242
[6]   Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus [J].
Scorpio, A ;
Zhang, Y .
NATURE MEDICINE, 1996, 2 (06) :662-667
[7]   EXOGENOUS REINFECTION WITH MULTIDRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS IN PATIENTS WITH ADVANCED HIV-INFECTION [J].
SMALL, PM ;
SHAFER, RW ;
HOPEWELL, PC ;
SINGH, SP ;
MURPHY, MJ ;
DESMOND, E ;
SIERRA, MF ;
SCHOOLNIK, GK .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (16) :1137-1144