Direct C-H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

被引：512

作者：

Seiple, Ian B. ^{[1
]}

Su, Shun ^{[1
]}

Rodriguez, Rodrigo A. ^{[1
]}

Gianatassio, Ryan ^{[1
]}

Fujiwara, Yuta ^{[1
]}

Sobel, Adam L. ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem & Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 38期

基金：

日本学术振兴会;

关键词：

CATALYZED DIRECT ARYLATION; AROMATIC-SUBSTITUTION; PYRIDINES; PHENYLATION; RADICALS;

D O I：

10.1021/ja1066459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate cooxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.

引用

页码：13194 / 13196

页数：3

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