Parasite role reversal: worms on trial

被引:49
作者
Falcone, FH [1 ]
Pritchard, DI [1 ]
机构
[1] Sch Pharm, Immune Modulat Res Grp, Nottingham NG7 2RD, England
关键词
D O I
10.1016/j.pt.2005.02.002
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Asthma has reached epidemic proportions globally. This has been attributed by many to improved hygiene. The frequent failure of conventional pharmaceuticals to manage the disease has led to the introduction of parasites as a potential alternative therapy for asthma and other immunological diseases. In this article, we briefly review the immunological rationale underpinning therapeutic parasitic infection, describe recently initiated trials, and highlight potential risks and benefits of introducing parasites into patient cohorts.
引用
收藏
页码:157 / 160
页数:4
相关论文
共 42 条
[1]   An enteric helminth infection protects against an allergic response to dietary antigen [J].
Bashir, MEH ;
Andersen, P ;
Fuss, IJ ;
Shi, HN ;
Nagler-Anderson, C .
JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3284-3292
[2]   Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics [J].
Cooper, PJ ;
Chico, ME ;
Rodrigues, LC ;
Ordonez, M ;
Strachan, D ;
Griffin, GE ;
Nutman, TB .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (05) :995-1000
[3]   Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells [J].
Dahl, ME ;
Dabbagh, K ;
Liggitt, D ;
Kim, S ;
Lewis, DB .
NATURE IMMUNOLOGY, 2004, 5 (03) :337-343
[4]   Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice [J].
Elliott, DE ;
Setiawan, T ;
Metwali, A ;
Blum, A ;
Urban, JF ;
Weinstock, JV .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (10) :2690-2698
[5]   Exposure to schistosome eggs protects mice from TNBS-induced colitis [J].
Elliott, DE ;
Li, J ;
Blum, A ;
Metwali, A ;
Qadir, K ;
Urban, JF ;
Weinstock, JV .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2003, 284 (03) :G385-G391
[6]   Does the failure to acquire helminthic parasites predispose to Crohn's disease? [J].
Elliott, DE ;
Urban, JF ;
Argo, CK ;
Weinstock, JV .
FASEB JOURNAL, 2000, 14 (12) :1848-1855
[7]   The innate allergenicity of helminth parasites [J].
Falcone, FH ;
Loukas, A ;
Quinnell, RJ ;
Pritchard, DI .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2004, 26 (01) :61-72
[8]  
GODFREY R C, 1975, Clinical Allergy, V5, P201, DOI 10.1111/j.1365-2222.1975.tb01853.x
[9]   Intestinal nematode infection ameliorates experimental colitis in mice [J].
Khan, WI ;
Blennerhasset, PA ;
Varghese, AK ;
Chowdhury, SK ;
Omsted, P ;
Deng, Y ;
Collins, SM .
INFECTION AND IMMUNITY, 2002, 70 (11) :5931-5937
[10]   Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae [J].
Le Goff, L ;
Martin, C ;
Oswald, IP ;
Vuong, PN ;
Petit, G ;
Ungeheuer, MN ;
Bain, O .
PARASITOLOGY, 2000, 120 :271-280