Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

被引：69

作者：

Kerkhof, H. J. M. ^{[1
,11
]}

Doherty, M. ^{[2
]}

Arden, N. K. ^{[3
,4
]}

Abramson, S. B. ^{[5
]}

Attur, M. ^{[5
]}

Bos, S. D. ^{[1
,6
]}

Cooper, C. ^{[3
,4
]}

Dennison, E. M. ^{[3
]}

Doherty, S. A. ^{[2
]}

Evangelou, E. ^{[7
]}

Hart, D. J. ^{[8
]}

Hofman, A. ^{[9
]}

Javaid, K. ^{[4
]}

Kerna, I. ^{[10
]}

Kisand, K. ^{[10
,12
]}

Kloppenburg, M. ^{[13
]}

Krasnokutsky, S. ^{[5
]}

Maciewicz, R. A. ^{[14
]}

Meulenbelt, I. ^{[6
]}

Muir, K. R. ^{[15
,16
]}

Rivadeneira, F. ^{[1
,9
,11
]}

Samuels, J. ^{[5
]}

Sezgin, M. ^{[17
]}

Slagboom, E. ^{[1
,6
]}

Smith, A. J. P. ^{[18
]}

Spector, T. D. ^{[8
]}

Tamm, A. ^{[10
,19
]}

Uitterlinden, A. G. ^{[1
,9
]}

Wheeler, M. ^{[2
]}

Zhai, G. ^{[8
]}

Zhang, W. ^{[2
]}

van Meurs, J. B. J. ^{[1
,11
]}

Valdes, A. M. ^{[8
]}

机构：

[1] NGI NCHA, Rotterdam, Netherlands

[2] City Hosp Nottingham, Acad Rheumatol, Nottingham NG5 1PB, England

[3] Univ Southampton, Southampton Gen Hosp, MRC Epidemiol Resource Ctr, Southampton SO16 6YD, Hants, England

[4] Univ Oxford, Dept Orthopaed Rheumatol & Musculoskeletal Sci, NIHR Musculoskeletal Biomed Res Unit, Oxford OX3 7LD, England

[5] NYU, Sch Med, Dept Med, Div Rheumatol, New York, NY 10016 USA

[6] Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands

[7] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece

[8] Kings Coll London, St Thomas Hosp, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[9] Erasmus MC, Dept Epidemiol, NL-3000 DR Rotterdam, Netherlands

[10] Univ Tartu, Dept Internal Med, Tartu, Estonia

[11] Erasmus MC, Genet Lab, Dept Internal Med, NL-3000 DR Rotterdam, Netherlands

[12] Univ Tartu, Inst Gen & Mol Pathol, Immunol Grp, Tartu, Estonia

[13] Leiden Univ, Med Ctr, Dept Rheumatol & Clin Epidemiol, Leiden, Netherlands

[14] AstraZeneca, Charnwood R&D, Resp & Inflammat Res Area, Loughborough LE11 5RH, Leics, England

[15] Univ Warwick, Coventry CV4 7AL, W Midlands, England

[16] Warwick Med Sch, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England

[17] Mersin Univ, Fac Med, Dept Phys Med & Rehabil, Mersin, Turkey

[18] UCL, Ctr Cardiovasc Genet, Dept Med, London, England

[19] Univ Tartu, Dept Sport Med & Rehabil, Tartu, Estonia

来源：

OSTEOARTHRITIS AND CARTILAGE | 2011年 / 19卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Osteoarthritis; IL-1; Interleukin; Genetic; Association; Polymorphism; GENOME-WIDE ASSOCIATION; BONE-MINERAL DENSITY; MEULENBELT ET-AL; GENE-CLUSTER; POPULATION; SUSCEPTIBILITY; HETEROGENEITY; OSTEOPOROSIS; CHINGFORD; ARTICLE;

D O I：

10.1016/j.joca.2010.12.003

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Objective: To clarify the role of common genetic variation in the Interleukin-1 beta (IL1B) and Interleukin-1R antagonist (IL1RN) genes on risk of knee and hip osteoarthritis (OA) and severity of knee OA by means of large-scale meta-analyses. Methods: We searched PubMed for articles assessing the role of IL1B and IL1RN polymorphisms/haplotypes on the risk of hip and/or knee OA. Novel data were included from eight unpublished studies. Meta-analyses were performed using fixed- and random-effects models with a total of 3595 hip OA and 5013 knee OA cases, and 6559 and 9132 controls respectively. The role of ILRN haplotypes on radiographic severity of knee OA was tested in 1918 cases with Kellgren-Lawrence (K/L) 1 or 2 compared to 199 cases with K/L 3 or 4. Results: The meta-analysis of six published studies retrieved from the literature search and eight unpublished studies showed no evidence of association between common genetic variation in the IL1B or IL1RN genes and risk of hip OA or knee OA (P > 0.05 for rs16944, rs1143634, rs419598 and haplotype C-G-C (rs1143634, rs16944 and rs419598) previously implicated in risk of hip OA). The C-T-A haplotype formed by rs419598, rs315952 and rs9005, previously implicated in radiographic severity of knee OA, was associated with reduced severity of knee OA (odds ratio (OR) = 0.71 95% CI 0.56-0.91; P = 0.006, I(2) = 74%), and achieved borderline statistical significance in a random-effects model (OR = 0.61 95% CI 0.35-1.06 P=0.08). Conclusion: Common genetic variation in the Interleukin-1 region is not associated with prevalence of hip or knee OA but our data suggest that IL1RN might have a role in severity of knee OA. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：265 / 271

页数：7

共 33 条

[1]

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis [J].

Abdin-Mohamed, M. ;

Jameson, K. ;

Dennison, E. M. ;

Cooper, C. ;

Arden, N. K. .

OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (02) :174-177

[2]

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations [J].

Attur, Mukundan ;

Wang, Hwa-Ying ;

Kraus, Virginia Byers ;

Bukowski, Jack F. ;

Aziz, Nazneen ;

Krasnokutsky, Svetlana ;

Samuels, Jonathan ;

Greenberg, Jeffrey ;

McDaniel, Gary ;

Abramson, Steven B. ;

Kornman, Kenneth S. .

ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (05) :856-861

[3]

Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[4]

Synovial tissue inflammation in early and late osteoarthritis [J].

Benito, MJ ;

Veale, DJ ;

Fitzgerald, O ;

van den Berg, WB ;

Bresnihan, B .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (09) :1263-1267

[5]

Association of the interleukin-1 gene cluster with osteoarthritis of the hip: comment on the article by Meulenbelt et al and the letter by Smith et al [J].

Chapman, Kay ;

Loughlin, John .

ARTHRITIS AND RHEUMATISM, 2006, 54 (11) :3722-3723

[6]

THE COMBINATION OF ESTIMATES FROM DIFFERENT EXPERIMENTS [J].

COCHRAN, WG .

BIOMETRICS, 1954, 10 (01) :101-129

[7]

Pathogenesis and management of pain in osteoarthritis [J].

Dieppe, PA ;

Lohmander, LS .

LANCET, 2005, 365 (9463) :965-973

[8]

Engels EA, 2000, STAT MED, V19, P1707, DOI 10.1002/1097-0258(20000715)19:13<1707::AID-SIM491>3.0.CO

[9]

2-P

[10]

The regulation of chondrocyte function by proinflammatory mediators -: Prostaglandins and nitric oxide [J].

Goldring, MB ;

Berenbaum, F .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2004, (427) :S37-S46

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