Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

被引:8
作者
Bronoosh, P. [1 ]
Tanideh, N. [2 ,3 ]
Noorafshan, A. [4 ]
Tadbir, A. Andisheh [5 ,6 ]
Aalipanah, M. [7 ]
Kamali, F. [6 ]
Abbasnia, K. [8 ]
Koohi-Hosseinabadi, O. [9 ]
机构
[1] Shiraz Univ Med Sci, Dept Oral Radiol, Sch Dent, Shiraz 7134873985, Iran
[2] Shiraz Univ Med Sci, Stem Cell & Transgen Technol Res Ctr, Shiraz 7134873985, Iran
[3] Shiraz Univ Med Sci, Dept Pharmacol, Sch Med, Shiraz 7134873985, Iran
[4] Shiraz Univ Med Sci, Histomorphometry & Stereol Res Ctr, Shiraz 7134873985, Iran
[5] Shiraz Univ Med Sci, Oral & Dent Hlth Care Res Ctr, Shiraz 7134873985, Iran
[6] Shiraz Univ Med Sci, Dept Oral & Maxillofacial Pathol, Sch Dent, Shiraz 7134873985, Iran
[7] Shiraz Univ Med Sci, Student Res Comm, Sch Dent, Shiraz 7134873985, Iran
[8] Shiraz Univ Med Sci, Dept Physiotherapy, Sch Rehabil, Shiraz 7134873985, Iran
[9] Shiraz Univ Med Sci, Lab Anim Ctr, Shiraz 7134873985, Iran
关键词
LIPU; healing; mandible; histology; stereology; rabbit; CONTROLLED SINGLE-BLIND; THERAPEUTIC ULTRASOUND; STIMULATE OSTEOCONDUCTION; PATHOLOGICAL RESEARCH; RATS; OSTEOBLASTS; DIAGNOSIS; MEMBRANES; DISECTOR; CALLUS;
D O I
10.1016/j.ijom.2014.09.020
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
Research evidence suggests that low-intensity pulsed ultrasound (LIPU) produces significant osteoinductive effects, accelerating the healing of bon6 defects. The authors investigated the effects of LIPU on mandibular bone defects in a rabbit model. Fifty-six adult Dutch rabbits were divided randomly into control, LIPU-1 (1 MHz), and LIPU-3 (3 MHz) groups. A mandibular defect was created in all rabbits. The effect of LIPU on mandibular defects was assessed by frequency (1 or 3 MHz) and timing (2 and 4 weeks). Bone mineral density (BMD) was measured and stereology and histology performed; results were compared at the end of 2 and 4 weeks. LIPU-3 resulted in significantly higher bone formation compared to the control group at the end of week 4 on histological assessment (P = 0.008). BMD was significantly higher at 4 weeks than at 2 weeks (P = 0.03). LIPU-3 increased the numerical density of osteoblasts and osteocytes at the end of week 4 (P = 0.05 and P = 0.001, respectively). The results of this study are in favour of using LIPU 3 MHz to accelerate mandibular bone healing. However, this study suggests that a frequency of 3 MHz and the longer application of LIPU 3 MHz for 4 weeks can only promote 8% mandibular bone healing in rabbits. Therefore, the use of LIPU has no really convincing, consistent clinical effects on maxillofacial bone healing.
引用
收藏
页码:277 / 284
页数:8
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