Apoptosis and cytotoxicity of oligo(styrene-co-acrylonitrile)-modified montmorillonite

被引：17

作者：

Liu, Qian ^{[2
]}

Liu, Yachun ^{[1
,2
]}

Xiang, Shuanglin ^{[2
]}

Mo, Xiaojun ^{[1
]}

Su, Shengpei ^{[1
]}

Zhang, Jian ^{[2
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Sustainable Resources Proc & Adv Mat Huna, Changsha 410081, Hunan, Peoples R China

[2] Hunan Normal Univ, Key Lab Prot Chem & Dev Biol, Minist Educ China, Coll Life Sci, Changsha 410081, Hunan, Peoples R China

来源：

APPLIED CLAY SCIENCE | 2011年 / 51卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cytotoxicity; Apoptosis; Montmorillonite; Oligo(styrene-co-acrylonitrile); CATIONIC DRUGS; ORAL DELIVERY; CLAY-MINERALS; RELEASE; ADSORPTION; INTERCALATION; INDUCTION; SMECTITE; SYSTEM; ACID;

D O I：

10.1016/j.clay.2010.11.019

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

To evaluate the cytotoxic effect and the mechanism of the apoptosis of oligo(styrene-co-acrylonitrile)modified montmorillonite (PSAN-MMT), the present study is focused on the involvement of antiproliferation, lactate dehydrogenase release, apoptosis level, caspase 3 activity, transcriptional activity of apoptosis-related gene and apoptosis-related protein and mRNA level. Non-cytotoxic montmorillonite (MMT) incubated cells were used as control. Little cytotoxicity was observed in PSAN-MMT treated cells, and lower level of apoptosis was induced by PSAN-MMT when cells were incubated with high montmorillonite content (1 g/L). The apoptosis seemed to follow a transcription-dependent route by activating proapoptotic genes such as p53 and p21. The modified MMT could be a promising candidate of biosafety controlled-release carrier for large drug molecules and for gene delivery. (c) 2010 Elsevier B.V. All rights reserved.

引用

页码：214 / 219

页数：6

共 33 条

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