Innate immunity and autoimmunity: from self-protection to self-destruction

被引：107

作者：

Shi, FD

Ljunggren, HG

Sarvetnick, N

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Karolinska Inst, Microbiol & Tumor Biol Ctr, S-17177 Stockholm, Sweden

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4906(00)01821-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.

引用

页码：97 / 101

页数：5

共 50 条

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