Dynamics of B cells in germinal centres

被引：797

作者：

De Silva, Nilushi S.

Klein, Ulf ^{[1
]}

机构：

[1] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

FOLLICULAR HELPER-CELL; PRIMARY IMMUNE-RESPONSE; PLASMA-CELL; MEMORY B; ANTIBODY-RESPONSES; CENTER SELECTION; GENE-EXPRESSION; CUTTING EDGE; DARK ZONE; CYCLIN D3;

D O I：

10.1038/nri3804

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Humoral immunity depends on the germinal centre (GC) reaction during which somatically mutated high-affinity memory B cells and plasma cells are generated. Recent studies have uncovered crucial cues that are required for the formation and the maintenance of GCs and for the selection of high-affinity antibody mutants. In addition, it is now clear that these events are promoted by the dynamic movements of cells within and between GCs. These findings have resolved the complexities of the GC reaction in greater detail than ever before. This Review focuses on these recent advances and discusses their implications for the establishment of humoral immunity. of

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收藏

页码：137 / 148

页数：12

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