DNA-encoded chemical libraries of macrocycles

被引：31

作者：

Connors, William H. ^{[1
]}

Hale, Stephen P. ^{[1
]}

Terrett, Nicholas K. ^{[1
]}

机构：

[1] Ensemble Therapeut Corp, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2015年 / 26卷

关键词：

INSULIN-DEGRADING ENZYME; HIGH-FAT DIET; NATURAL-PRODUCTS; DRUG DISCOVERY; PEPTIDE; INHIBITORS; SELECTION; APOPTOSIS; PROTEINS; GLUCOSE;

D O I：

10.1016/j.cbpa.2015.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Conformationally constrained macrocyclic molecules can present functionally diverse chemical groups distributed over a relatively large molecular surface. This class of molecule is well suited to bind to the extended interface surfaces typical of protein-protein interactions that make up key therapeutically relevant pathways. Large numbers of macrocycles can be generated using DNA-encoded technologies to yield chemically diverse libraries where individual macrocycles are identifiable by a unique covalently attached DNA sequence. Recent developments in this field have revealed library-generated macrocycles possessing potent affinity against tough targets such as XIAP, IL17 and IDE. This review highlights recent progression toward developing drug-like macrocycles and as illustration, advances against these targets. © 2015 Elsevier Ltd.

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页码：42 / 47

页数：6

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